29 de febrero de 2012, DÍA MUNDIAL DE LAS ENFERMEDADES RARAS.

Por: Consejo de Redacción de SEPIS-2010 (29-2-2012)

Fuente: http://elrincondelamedicinainterna.blogspot.com/2008/07/cual-es-el-diagnstico_21.html

Hoy se celebra el día mundial de las enfermedades raras como por ejemplo la ARGIRIA.

La argiria es una enfermedad caracterizada por el cambio de color de la piel y otros órganos y tejidos (como la conjuntiva) del paciente, de su color natural a un color gris azulado, siendo especialmente más acusado este cambio en las zonas expuestas a la luz.
La argiria se produce por una exposición prolongada a plata y a las sales de plata. Se pueden encontrar casos de argiria generalizada o localizada (argirosis).

LOS PELIGROS DE LA PLATA COLOIDAL.

Fuente: http://salud.univision.com/es/hierbas-y-suplementos-a-z/plata-coloidal

La utilización de preparados de plata durante largos períodos puede causar argiria, una afección permanente en la cual los depósitos de sales de plata se depositan en la piel, ojos y órganos internos, por lo cual la apariencia de la piel se torna gris cenizo. Algunas veces se confunde la argiria con la enfermedad cianótica del corazón.

Actualmente, no se reconoce la plata coloidal como segura o efectiva. No obstante, algunos investigadores creen que tiene propiedades antibacterianas, lo cual puede dar pie a estudios adicionales. A pesar de la falta de evidencia científica disponible, la plata coloidal se usa de forma más común como antibiótico natural o agente curativo, y se usa aplicándola en la piel o en forma de bebida, a fin de promover la curación o combatir la enfermedad.

La Administración de Drogas y Alimentos de EE.UU. (FDA) ha emprendido acciones legales en contra de varias compañías de drogas coloidales así como contra anunciantes en las páginas de Internet, por hacer afirmaciones sin fundamentos acerca de sus productos. Los productos de plata coloidal a menudo se comercializan como suplementos alimenticios, por lo que sus fabricantes no requieren pasar por el mismo proceso riguroso de aprobación que se exige a las compañías farmacéuticas.

Efectos secundarios y advertencias

La plata coloidal es probablemente insegura por vía oral o aplicada a la piel. La Administración de Drogas y Alimentos de EE.UU. (FDA) emitió su decisión final en agosto de 1999 que establece que todos los medicamentos de venta sin receta médica que contenían ingredientes de plata coloidal o sales de plata para uso externo o interno, no se reconocían generalmente como seguros ni efectivos y que la información provista para su comercialización es incorrecta. Esta regulación fue emitida porque la plata coloidal se ha comercializado como efectiva para muchas enfermedades graves. Además, la plata coloidal también puede causar lesión renal, molestia estomacal, dolores de cabeza, fatiga e irritación de la piel.

No se recomienda que las mujeres embarazadas o lactantes usen plata coloidal debido a la falta de evidencia científica disponible.

Para más información sobre los efectos secundarios de la ingesta de plata coloidal, os adjuntamos algunos artículos científicos.

http://www.ncbi.nlm.nih.gov/pubmed/17177941

J Cutan Pathol. 2006 Dec;33(12):809-11.

A case of argyria after colloidal silver ingestion.

Chang ALKhosravi VEgbert B.

Source

Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305, USA. alschang@stanford.edu

Abstract

BACKGROUND:

Argyria is often considered an entity of the past, one which has largely disappeared with the cessation ofsilver usage in oral medications. However, with the practice of colloidal silver ingestion in current “alternative health” treatments, argyria should be considered in the differential diagnosis of blue-gray hyperpigmentation.

METHODS:

A single case report with clinicopathological correlation.

RESULTS:

Histological examination of skin biopsy specimen, which showed perieccrine brown-black granules, verified thatcolloidal silver rather than a prescribed medication was the source of the patient’s dyspigmentation.

PMID:17177941[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/15111684

Neurology. 2004 Apr 27;62(8):1408-10.

Myoclonic status epilepticus following repeated oral ingestion of colloidal silver.

Mirsattari SMHammond RRSharpe MDLeung FYYoung GB.

Source

Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.

Abstract

The authors report a case of a 71-year-old man who developed myoclonic status epilepticus and coma after daily ingestion ofcolloidal silver for 4 months resulting in high levels of silver in plasma, erythrocytes, and CSF. Despite plasmapheresis, he remained in a persistent vegetative state until his death 5.5 months later. Silver products can cause irreversible neurologictoxicity associated with poor outcome.

PMID:15111684[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/20883406

Int J Dermatol. 2010 Oct;49(10):1175-7. doi: 10.1111/j.1365-4632.2009.04380.x.

Three systemic argyria cases after ingestion of colloidal silver solution.

Chung ISLee MYShin DHJung HR.

Source

Division of Occupational and Environmental medicine, Department of Preventive Medicine, Keimyung University, Dongsan Medical Center, Daegu, Korea. ichungs@dsmc.or.kr

PMID:20883406[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/20523812

A case of argyria following colloidal silver ingestion.

Kwon HBLee JHLee SHLee AYChoi JSAhn YS.

Source

Department of Dermatology, Dongguk University International Hospital, College of Medicine, Dongguk University, Goyang, Korea.

Abstract

Argyria is a rare cutaneous discoloration caused by the intake of silver or various compounds containing silver. We report a case of argyria in a 73-year-old male following ingestion of colloidal silver as an alternative medicine over 5 years. He had a diffuse, slate gray discoloration of his face and hands. A biopsy specimen from the face revealed brown-black extracellular granules in the upper dermis and between collagen bundles. We also found silver particles in the mucous of the colon. The ingestion of colloidal silver appears to be increasing among patients using alternative health practices. We report this case to bring people’s attention to the problems associated with the ingestion of colloidal silver.

PMID:20523812[PubMed] PMCID:PMC2861249

Free PMC Article

 

http://www.ncbi.nlm.nih.gov/pubmed/19097083

Am J Ind Med. 2009 Mar;52(3):246-50.

A case of generalized argyria after ingestion of colloidal silver solution.

Kim YSuh HSCha HJKim SHJeong KSKim DH.

Source

Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea. yanghokm@nuri.net

Abstract

A 58-year-old woman was referred to our hospital due to progressive skin darkening, which began 5 months previously. The patient had strikingly diffuse blue-gray discoloration of the skin, most prominent in sun-exposed areas, especially her face and hands. The oral mucosa, tongue, gums, eye conjunctiva, ears, nail beds, and trunk were also involved. Bluish-gray discoloration of all nails was aggravated by cold weather. She had ingested 1 L of colloidal silver solution daily for approximately 16 months as a traditional remedy. Her serum silver concentration was 381 ng/ml which was a very high (reference level: <15 ng/ml). Light microscopic examination of a punch biopsy specimen from her nose revealed fine, minute, round, and brown-black granules deposited in the basement membrane of hair follicular epithelium. Scanning electron microscopic examination showed electron-dense granules deposited in the intercellular space of sweat glands. Energy disperse X-ray spectrometry analysis demonstrated peaks for silver and sulfur in the dense black deposits. The ingestion ofcolloidal silver appears to be an increasing practice among patients using alternative health practices. All silver-containing products including colloidal silver should be labeled with a clear warning to prevent argyria, especially in alternative health practices.

PMID:19097083[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/18025945

Curr Opin Pediatr. 2007 Dec;19(6):733-5.

Case report: skin discoloration following administration of colloidal silver in cystic fibrosis.

Baker CDFederico MJAccurso FJ.

Source

Department of Pediatrics, The Children’s Hospital, 1056 E. 19th Ave., Box B-395, Denver, CO 80218, USA. christopher.baker@uchsc.edu

Abstract

PURPOSE OF REVIEW:

Complementary and alternative medicine therapies are frequently combined with conventional medical treatment and can significantly affect patient care. In the following case, an adjunctive modality posed a significant health risk to the patient.

RECENT FINDINGS:

An 11-year-old boy with cystic fibrosis reported a bluish skin color after he began ingesting a colloidalsilver solution to facilitate mucus clearance. Serum silver level was elevated to more than twice the upper limit of normal. This finding is highly suggestive of argyria, a typically permanent discoloration of the skin due to dermal silver deposits. In this child, however, the discoloration was transient and the silver level normalized when the therapy was discontinued.

SUMMARY:

Although a diagnosis of argyria was not formally made, this case reviews the known dangers associated withsilver ingestion. Complementary and alternative medicine therapies are common and can both augment and interfere with the traditional standard of care. Informed providers who inquire about the use of these therapies can then discuss the risks and benefits of each utilized modality.

PMID:18025945[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/16021155

J Am Acad Dermatol. 2005 Aug;53(2 Suppl 1):S105-7.

Argyria secondary to ingestion of homemade silver solution.

Brandt DPark BHoang MJacobe HT.

Source

Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Abstract

Argyria is a rare skin disease caused by cutaneous deposition of silver granules in the skin as a result of exposure to silversubstrate or ingestion of silver salt. This report describes a patient with generalized argyria caused by ingestion of homemade colloidal silver solution. The patient learned about the uses of the silver solution and its preparation at a convention for “natural medicine.”

PMID:16021155[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/15748553

Dermatol Online J. 2005 Mar 1;11(1):12.

Systemic argyria associated with ingestion of colloidal silver.

Wadhera AFung M.

Source

Department of Dermatology, University of California Davis, USA.

PMID:15748553[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/12839605

Int J Dermatol. 2003 Jul;42(7):549.

Argyria associated with colloidal silver supplementation.

McKenna JKHull CMZone JJ.

Source

Department of Dermatology, University of Utah, Salt Lake City, UT 84132, USA.

Abstract

A 65-year-old male presented for skin examination and was incidentally noted to have discoloration of the fingernails. These findings were completely asymptomatic. The patient had been taking colloidal silver supplementation (Silverzone 140 ppmsilver Gifts of Nature, St. George, UT, USA) for 2 years as therapy for diabetes. He first noticed the onset of nail discoloration 1 year ago. His past medical history included type II diabetes and hypertension. His current medications were metformin, glyburide, and benazepril. Physical examination revealed slate-gray discoloration involving the lunulae of the fingernails (Fig. 1). The skin, mucous membranes, and sclerae were unaffected.

PMID:12839605[PubMed – indexed for MEDLINE]

 

http://www.ncbi.nlm.nih.gov/pubmed/12780705

Clin Exp Dermatol. 2003 May;28(3):254-6.

Severe generalized argyria secondary to ingestion of colloidal silver protein.

White JMPowell AMBrady KRussell-Jones R.

Source

Department of Dermatology, Ealing Hospital, London, UK. jonathanmlwhite@hotmail.com

Abstract

Argyria is a rare cause of cutaneous discolouration caused by silver deposition. We report a case of dramatic and diffuseargyria secondary to ingestion of colloidal silver protein over a 1-year period. Stained electron microscopy with spectral analysis was used to confirm the clinical diagnosis. Silver-protein complexes are deposited in the skin and reduced to inertsilver salts by sunlight in a process similar to that harnessed in photography. Our patient had obtained the silver for consumption via mail order. It had been advertised as a cure for a variety of diseases. Colloidal silver protein is commercially available as a ‘food supplement’, hence circumventing the strict controls placed on medicines.

PMID:12780705[PubMed – indexed for MEDLINE]

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